Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150.

@article{Ghisi2011ModulationOM,
  title={Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150.},
  author={M. Ghisi and A. Corradin and K. Basso and C. Frasson and Valentina Serafin and Subhamoy Mukherjee and L. Mussolin and K. Ruggero and L. Bonanno and A. Guffanti and G. de Bellis and G. Gerosa and G. Stellin and D. D'agostino and G. Basso and V. Bronte and S. Indraccolo and A. Amadori and P. Zanovello},
  journal={Blood},
  year={2011},
  volume={117 26},
  pages={
          7053-62
        }
}
Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly understood. The present study investigated microRNAs involved in human thymocyte differentiation by comparing the microRNA expression profiles of thymocytes at the double-positive, single-positive CD4(+) and single-positive CD8(+) maturation stages. Microarray analysis showed that each thymocyte population displays a distinct microRNA expression profile that reflects their developmental relationships… Expand
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