Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells.

  title={Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells.},
  author={Y. Xuan and M. Hacker and T. Tritton and A. Bhushan},
  journal={Oncology reports},
  volume={5 2},
  • Y. Xuan, M. Hacker, +1 author A. Bhushan
  • Published 1998
  • Biology, Medicine
  • Oncology reports
  • We have previously shown that methotrexate (MTX) transport is impaired in murine L1210 cells selected for cisplatin (DDP) resistance (L1210/DDP) and that the decreased MTX uptake may be due to an altered 66 kDa membrane protein. We have further hypothesized that tyrosine phosphorylation is necessary for the function of this protein. To determine the importance of tyrosine phosphorylation we studied the effect of genistein, a tyrosine kinase inhibitor, on methotrexate sensitivity, uptake and… CONTINUE READING
    6 Citations
    Collateral methotrexate resistance in cisplatin-selected murine leukemia cells.
    • A. Bhushan, M. Hacker, T. Tritton
    • Medicine, Biology
    • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
    • 1999
    • 3
    • PDF
    Identification and characterization of a 66–68-kDa protein as a methotrexate-binding protein in murine leukemia L1210 cells
    • 5
    Tyrosine Kinase Inhibitors in Preclinical Development
    • 49