Modulation of memory storage

@article{Cahill1996ModulationOM,
  title={Modulation of memory storage},
  author={Larry Cahill and J. D. McGaugh},
  journal={Current Opinion in Neurobiology},
  year={1996},
  volume={6},
  pages={237-242}
}
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291 Citations
Highly Influential Citations
9
Background Citations
110
Methods Citations
2
Results Citations
11

291 Citations

The role of the noradrenergic system in emotional memory.
Interactions between catecholamines and the amygdala in emotional memory: subclinical and clinical evidence.
  • L. Cahill
  • Biology, Psychology
    Advances in pharmacology
  • 1998
Involvement of the amygdala in memory storage: interaction with other brain systems.
TLDR
Findings provide strong evidence supporting the hypothesis that the amygdala is involved in modulating long-term memory storage, as well as supporting the central hypothesis guiding the research reviewed in this paper.
Retrieval of emotional memories.
  • T. Buchanan
  • Psychology, Biology
    Psychological bulletin
  • 2007
TLDR
The review of the literature addressing the effects of emotion on retrieval suggests that the amygdala, in combination with the hippocampus and prefrontal cortex, plays an important role in the retrieval of memories for emotional events.
Memory for emotional events: differential effects of centrally versus peripherally acting β-blocking agents
TLDR
The results support the view that memory of a mild emotional event involves activation of central, but not necessarily peripheral β-adrenergic receptors, while propranolol impaired memory in subjects who saw the emotional version of the slide show.
Amygdala-hippocampus dynamic interaction in relation to memory
TLDR
A system, composed of the amygdala and the hippocampus, that acts synergistically to form long-term memories of significantly emotional events is described.
Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms.
  • A. Arnsten
  • Biology, Psychology
    Progress in brain research
  • 2000
The effect of beta-adrenergic blockade after encoding on memory of an emotional event
TLDR
This experiment does not support a role for noradrenaline in the post-encoding phase and on the later processes of consolidation and retrieval, and it remains possible that with a different dosage or timing protocol a post-treatment effect of noradRenaline in humans can be found.
beta-Adrenergic blockade and emotional memory in PTSD.
TLDR
PTSD and control subjects did not differ in the acquisition and retention of memories under emotionally arousing or emotionally neutral conditions, nor were differential effects of propranolol observed between the two groups.
The biochemistry of memory formation and its regulation by hormones and neuromodulators
TLDR
A key role in memory modulation of dopaminergic synapses, of brain benzodiazepine-like substances, and perhaps of serotonin acting at specific steps of the biochemistry of memory processes in the hippocampus, amygdala, or elsewhere is demonstrated.
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References

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Hormonal modulation of memory.
Beta-adrenergic activation and memory for emotional events.
TLDR
It is reported here that propranolol significantly impaired memory of the emotionally arousing story but did not affect memory ofThe emotionally neutral story, which supports the hypothesis that enhanced memory associated with emotional experiences involves activation of the beta-adrenergic system.
Stress and cognitive function
The possible contribution of the amygdala to memory.
The processing of episodic memories is believed to depend on the proper functioning of so-called bottleneck structures through which information apparently must pass in order to be stored long term.…
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
TLDR
The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.
Depletion of adrenal catecholamines alters the amnestic effect of amygdala stimulation
The memory-modulatory effects of glucocorticoids depend on an intact stria terminalis
Beta-adrenergic receptor antagonist antihypertensive medications impair arousal-induced modulation of working memory in elderly humans.
Glucocorticoid-induced impairment in declarative memory performance in adult humans
TLDR
Investigation of the cognitive consequences of DEX treatment in normal adult human subjects hypothesizing a decrease in declarative memory performance after extended but not overnight treatment found correct paragraph recall improved over the course of treatment, consistent with practice.
Modulation of memory processing by cholecystokinin: dependence on the vagus nerve.
TLDR
Cholecystokinin-octapeptide (CCK-8), which is a gastrointestinal hormone released during feeding, enhances memory retention when administered intraperitoneally, and may mediate the memory-enhancing effects of feeding.
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