Modulation of memory processing by cholecystokinin: dependence on the vagus nerve.

@article{Flood1987ModulationOM,
  title={Modulation of memory processing by cholecystokinin: dependence on the vagus nerve.},
  author={James Flood and Gary E. Smith and J Eileen Morley},
  journal={Science},
  year={1987},
  volume={236 4803},
  pages={832-4}
}
Allowing mice access to food immediately after an aversive training session enhances memory retention. Cholecystokinin-octapeptide (CCK-8), which is a gastrointestinal hormone released during feeding, also enhances memory retention when administered intraperitoneally. This memory-enhancing effect of CCK-8 is blocked when the vagus nerve is cut, indicating that CCK-8 may produce its effect on memory retention by activating ascending fibers in the vagus nerve. Thus, CCK-8, a peripherally acting… CONTINUE READING