Modulation of memory by post-training epinephrine: involvement of cholinergic mechanisms

@article{IntroiniCollison2004ModulationOM,
  title={Modulation of memory by post-training epinephrine: involvement of cholinergic mechanisms},
  author={Ines B. Introini-Collison and J. D. McGaugh},
  journal={Psychopharmacology},
  year={2004},
  volume={94},
  pages={379-385}
}
Extensive evidence indicates that memory storage can be modulated by peripheral epinephrine as well as by drugs affecting the muscarinic cholinergic system. Low doses of epinephrine (Epi) facilitate memory while high doses induce amnesia. Retention is enhanced by post-training administration of cholinergic muscarinic agonists and impaired by antagonists. The present experiments examined the interaction of peripheral Epi and cholinergic drugs in memory modulation. Male CFW mice (60 days old… 

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References

SHOWING 1-10 OF 93 REFERENCES

Naloxone and β-endorphin alter the effects of post-training epinephrine on memory

TLDR
It is found that a novel experience given 1 h prior to training blocked the memory-impairing effect of post-training Epi otherwise obtained in both tasks, indicating that theMemory-enhancing and memory-Impairing effects of Epi are mediated by different mechanisms.

Cholinergic modulation of memory in rats

TLDR
Seven cholinergic drugs with diverse modes of action were found to enhance 72-h retention of passive avoidance; however, the effective doses were different for each of the drugs studied.

Possible interaction between central cholinergic muscarinic and opioid peptidergic systems during memory consolidation in mice.

Memory retention: Effect of prolonged cholinergic stimulation in mice

Attenuation of scopolamine-induced amnesia in mice

TLDR
The results support the value of scopolamine as a model of age-related memory impairments, but suggest further that these memory deficits may be particularly susceptible to attenuation with non-cholinergic treatments.
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