Modulation of membrane transport of alkylating agents and amino acids by an analog of vasopressin in murine L5178Y lymphoblasts in vitro.

@article{Miller1987ModulationOM,
  title={Modulation of membrane transport of alkylating agents and amino acids by an analog of vasopressin in murine L5178Y lymphoblasts in vitro.},
  author={L. Miller and N. Kobrinsky and G. Goldenberg},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 1},
  pages={
          169-76
        }
}
  • L. Miller, N. Kobrinsky, G. Goldenberg
  • Published 1987
  • Chemistry, Medicine
  • Biochemical pharmacology
  • The synthetic vasopressin analog 1-deamino-8-D-arginine vasopressin (dDAVP) has been shown to influence a wide range of cell-membrane-related events. Accordingly, the effect of dDAVP on membrane transport of various alkylating agents and amino acids was evaluated in L5178Y lymphoblasts in vitro. dDAVP stimulated melphalan uptake but conversely inhibited uptake of nitrogen mustard, choline (the natural transport substrate for the nitrogen mustard carrier), and leucine. No effect on the uptake of… CONTINUE READING
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