Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.

  title={Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.},
  author={J. Wang and Meiyun Ma and S. Locovei and R. Keane and G. Dahl},
  journal={American journal of physiology. Cell physiology},
  volume={293 3},
  • J. Wang, Meiyun Ma, +2 authors G. Dahl
  • Published 2007
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • Connexin mimetic peptides are widely used to assess the contribution of nonjunctional connexin channels in several processes, including ATP release. These peptides are derived from various connexin sequences and have been shown to attenuate processes downstream of the putative channel activity. Yet so far, no documentation of effects of peptides on connexin channels has been presented. We tested several connexin and pannexin mimetic peptides and observed attenuation of channel currents that is… CONTINUE READING

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    Publications referenced by this paper.
    Connexins, connexons, and intercellular communication.
    • 1,185
    Gap junctions and the connexin protein family.
    • 853
    • Open Access
    Intracellular calcium changes trigger connexin 32 hemichannel opening
    • 231
    • Open Access
    Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication.
    • 190
    Pannexin 1 in erythrocytes: Function without a gap
    • 435
    • Open Access
    Attempts to define functional domains of gap junction proteins with synthetic peptides.
    • 81
    • Highly Influential
    • Open Access
    Selective inhibition of gap junction channel activity by synthetic peptides
    • 73
    • Open Access