Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.

@article{Wang2007ModulationOM,
  title={Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.},
  author={Jun-jie Wang and Meiyun Ma and Silviu Locovei and Robert W. Keane and Gerhard Dahl},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={293 3},
  pages={C1112-9}
}
Connexin mimetic peptides are widely used to assess the contribution of nonjunctional connexin channels in several processes, including ATP release. These peptides are derived from various connexin sequences and have been shown to attenuate processes downstream of the putative channel activity. Yet so far, no documentation of effects of peptides on connexin channels has been presented. We tested several connexin and pannexin mimetic peptides and observed attenuation of channel currents that is… CONTINUE READING
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