Modulation of matrix metalloprotease-2 and invasion in human glioma cells by alpha 3 beta 1 integrin.

@article{Chintala1996ModulationOM,
  title={Modulation of matrix metalloprotease-2 and invasion in human glioma cells by alpha 3 beta 1 integrin.},
  author={Shravan K. Chintala and Raymond A Sawaya and Ziya L. Gokaslan and J. Sunil Rao},
  journal={Cancer letters},
  year={1996},
  volume={103 2},
  pages={201-8}
}
We have investigated the effect of integrin antibodies to a well-characterized alpha 5 beta 1 (fibronectin receptor) and to a multi-specific alpha 3 beta 1 (laminin, collagen, and fibronectin receptor), on the expression of matrix metalloproteases and the invasion ability of two human glioblastoma cell lines, SNB19 and U251. Cell adhesion assays indicated that both cell lines adhere to fibronectin, type IV collagen and laminin. Adhesion of cells to fibronectin was inhibited by a RGD peptide… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…