Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness.

  title={Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness.},
  author={Emi Y. Tokuda and Jennifer L. Leight and Kristi S Anseth},
  volume={35 14},
Metastatic melanoma is highly resistant to drug treatment, and the underlying mechanisms of this resistance remain unclear. Increased tissue stiffness is correlated with tumor progression, but whether increased tissue stiffness contributes to treatment resistance in melanoma is not known. To investigate the effect of substrate stiffness on melanoma cell treatment responsiveness, PEG hydrogels were utilized as a cell culture system to precisely vary matrix elasticity and investigate melanoma… CONTINUE READING
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Cell-responsive synthetic hydrogels

MP Lutolf, GP Raeber, AH Zisch, N Tirelli, JA. Hubbell
Adv Mater 2003;15:888e92 • 2003
View 7 Excerpts
Highly Influenced

Thiol-ene click chemistry.

Angewandte Chemie • 2010
View 4 Excerpts
Highly Influenced

Tensional homeostasis and the malignant phenotype.

Cancer cell • 2005
View 4 Excerpts
Highly Influenced

The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels

SB Anderson, Lin C-C, DV Kuntzler, KS Anseth
Biomaterials 2011;32:3564e74. E.Y. Tokuda et al. / Biomaterials • 2014
View 1 Excerpt

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.

The New England journal of medicine • 2012
View 2 Excerpts