Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness.

@article{Tokuda2014ModulationOM,
  title={Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness.},
  author={Emi Y. Tokuda and Jennifer L. Leight and Kristi S Anseth},
  journal={Biomaterials},
  year={2014},
  volume={35 14},
  pages={
          4310-8
        }
}
Metastatic melanoma is highly resistant to drug treatment, and the underlying mechanisms of this resistance remain unclear. Increased tissue stiffness is correlated with tumor progression, but whether increased tissue stiffness contributes to treatment resistance in melanoma is not known. To investigate the effect of substrate stiffness on melanoma cell treatment responsiveness, PEG hydrogels were utilized as a cell culture system to precisely vary matrix elasticity and investigate melanoma… CONTINUE READING
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