Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.

@article{Diers2010ModulationOM,
  title={Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.},
  author={Anne R. Diers and Brian P. Dranka and Karina C. Ricart and Joo Yeun Oh and Michelle S. Johnson and Fen Zhou and Manuel Antonio Pallero and Thomas M. Bodenstine and Joanne E Murphy-Ullrich and Danny R Welch and Aimee L Landar},
  journal={The Biochemical journal},
  year={2010},
  volume={430 1},
  pages={69-78}
}
Recently, a number of steps in the progression of metastatic disease have been shown to be regulated by redox signalling. Electrophilic lipids affect redox signalling through the post-translational modification of critical cysteine residues in proteins. However, the therapeutic potential as well as the precise mechanisms of action of electrophilic lipids in cancer cells is poorly understood. In the present study, we investigate the effect of the electrophilic prostaglandin 15d-PGJ2 (15-deoxy… CONTINUE READING