Modulation of mammalian cardiac AMP deaminase by protein kinase C-mediated phosphorylation.

@article{Thakkar1993ModulationOM,
  title={Modulation of mammalian cardiac AMP deaminase by protein kinase C-mediated phosphorylation.},
  author={Jay K. Thakkar and David R Janero and Craig Yarwood and Haamid M. Sharif},
  journal={The Biochemical journal},
  year={1993},
  volume={291 ( Pt 2)},
  pages={523-7}
}
Using AMP deaminase (AMP aminohydrolase; EC 3.5.4.6) purified from rabbit left-ventricular heart tissue, we report direct investigation of the potential for cardiac AMP deaminase activity to be regulated by kinase-mediated phosphorylation. Rabbit heart AMP deaminase served as a substrate for Ca2+/phospholipid-dependent protein kinase (protein kinase C; PKC) exclusively; no other mammalian protein kinase phosphorylated the enzyme. PKC-dependent AMP deaminase phosphorylation was rapid, linear… CONTINUE READING

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