• Corpus ID: 37498253

Modulation of macronutrient metabolism in the offspring by maternal micronutrient deficiency in experimental animals.

@article{Raghunath2009ModulationOM,
  title={Modulation of macronutrient metabolism in the offspring by maternal micronutrient deficiency in experimental animals.},
  author={Manchala Raghunath and Lagishetty Venu and Inagadapa J.N. Padmavathi and Yedla Durga Kishore and Manisha Ganeshan and K Anand Kumar and Pothaganti B. Sainath and K. Rajender Rao},
  journal={The Indian journal of medical research},
  year={2009},
  volume={130 5},
  pages={
          655-65
        }
}
Epidemiological evidence indicates that poor early growth is associated with increased susceptibility to visceral obesity, insulin resistance and associated diseases in adulthood. Studies in experimental animals have demonstrated a robust association between nutrient imbalance during foetal life and disease prevalence in their later life specially of those involving macronutrient metabolism. There is very little data on the role of maternal micronutrient deficiencies widely prevalent in India… 

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References

SHOWING 1-10 OF 76 REFERENCES
Metabolic consequences of intrauterine growth retardation
  • C. N. Hales
  • Medicine
    Acta paediatrica (Oslo, Norway : 1992). Supplement
  • 1997
TLDR
Tests of the ‘thrifty phenotype’ hypothesis in an animal model in which pregnant and/or lactating rats were fed a diet with a reduced protein content have shown that liver metabolism in the offspring is permanently altered despite their being weaned onto a normal diet.
Micronutrient programming of development throughout gestation.
TLDR
Micronutrient imbalance can affect pregnancy outcome through alterations in maternal and conceptus metabolism, as a consequence of their essential role in enzymes and transcription factors and through their involvement in signal transduction pathways that regulate development.
The long-term consequences of intra-uterine protein malnutrition for glucose metabolism.
TLDR
Experiments in animal models show that the metabolism of the liver, muscle and adipose tissue may be programmed by maternal nutrition during gestation and lactation, and the combination of early growth restriction and subsequent adult obesity reproduced in the rat are the main features of the insulin resistance syndrome.
Does maternal dietary mineral restriction per se predispose the offspring to insulin resistance?
TLDR
Maternal MR per se resulted in an increase in body fat and in plasma triacylglycerol concentrations in the offspring, however, no discernable effect on insulin sensitivity over the first 180 days of life.
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring.
TLDR
Results show that unbalanced prenatal nutrition induces persistent, gene-specific epigenetic changes that alter mRNA expression that provides a strong candidate mechanism for fetal programming.
Maternal nutrient restriction affects properties of skeletal muscle in offspring
TLDR
It is demonstrated that the early to mid‐gestation period is important for skeletal muscle development, as impaired muscle development during this stage of gestation affects the number and composition of fibres in offspring which may lead to long‐term physiological consequences, including predisposition to obesity and diabetes.
Diet composition and insulin action in animal models
TLDR
It has been clear for some time that ‘oils ain't oils’, the same is now proving true for carbohydrates and proteins, and increased PUFA intake in animal models is associated with improved insulin action and reduced adiposity.
Effect of maternal vitamin and mineral restrictions on the body fat content and adipocytokine levels of WNIN rat offspring
TLDR
High body fat percentage in the offspring of vitamin restricted or mineral restricted rat dams was associated with increased abdominal adiposity (epididymal fat pad weight) and differential expression of adipocytokines but not insulin resistance.
Micronutrients in pregnancy
  • R. Black
  • Medicine
    British Journal of Nutrition
  • 2001
TLDR
Vitamins and minerals, referred to collectively as micronutrients, have important influences on the health of pregnant women and the growing fetus and on cost-effective public health interventions for their control.
...
1
2
3
4
5
...