Modulation of leak K(+) channel in hypoglossal motoneurons of rats by serotonin and/or variation of pH value.

@article{Xu2009ModulationOL,
  title={Modulation of leak K(+) channel in hypoglossal motoneurons of rats by serotonin and/or variation of pH value.},
  author={Xue-Feng Xu and Hao-Jan Tsai and Lin Li and Y F Chen and Cheng Zhang and Guang-fa Wang},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2009},
  volume={61 4},
  pages={305-16}
}
The cloned TWIK-related acid-sensitive K(+) channel (TASK-1) is sensitive to the pH changes within physiological pH range (pK~7.4). Recently, the native TASK-1-like channel was suggested to be the main contributor to the background (or leak) K(+) conductance in the motoneurons of the brain stem. Serotonin (5-HT) and variation of pH value in perfused solution could modulate these currents. Here we aimed to examine the properties and modulation of the currents by serotonin or variation of pH… CONTINUE READING

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