Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.

@article{Tsushima1999ModulationOI,
  title={Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.},
  author={R. Tsushima and A. Wickenden and R. Bouchard and G. Oudit and P. Liu and P. Backx},
  journal={Circulation research},
  year={1999},
  volume={84 11},
  pages={
          1302-9
        }
}
Heart failure is the leading cause of mortality in patients with transfusional iron (Fe) overload in which myocardial iron uptake ensues via a transferrin-independent process. We examined the ability of L-type Ca2+ channel modifiers to alter Fe2+ uptake by isolated rat hearts and ventricular myocytes. Perfusion of rat hearts with 100 nmol/L 59Fe2+ and 5 mmol/L ascorbate resulted in specific 59Fe2+ uptake of 20.4+/-1.9 ng of Fe per gram dry wt. Abolishing myocardial electrical excitability with… Expand
122 Citations
Fe2+ Block and Permeation of CaV3.1 (α1G) T-Type Calcium Channels: Candidate Mechanism for Non–Transferrin-Mediated Fe2+ Influx
  • 26
  • Highly Influenced
Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins
  • 1
Ferric iron uptake into cardiomyocytes of β-thalassemic mice is not through calcium channels
  • 15
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 70 REFERENCES
Effects of iron loading on uptake, speciation, and chelation of iron in cultured myocardial cells.
  • 69
Heart cells in culture: a model of myocardial iron overload and chelation.
  • 129
Characterization of a transferrin-independent uptake system for iron in HeLa cells.
  • 167
  • PDF
Regulation of the transferrin-independent iron transport system in cultured cells.
  • 190
  • PDF
...
1
2
3
4
5
...