Modulation of ionic currents in Aplysia motor neuron B15 by serotonin, neuropeptides, and second messengers.

  title={Modulation of ionic currents in Aplysia motor neuron B15 by serotonin, neuropeptides, and second messengers.},
  author={R A Taussig and A Sweet-Cordero and Richard H. Scheller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={9 9},
Both 5-HT and the 9 amino acid neuropeptide SCPb modulate 3 ionic currents in B15, enhancing a voltage-dependent inward sodium current, decreasing an outward potassium current and increasing an inward rectifying potassium current. In contrast, FMRFamide decreases a voltage-dependent inward sodium current and increases an outward potassium current. We have also investigated the roles of several second-messenger systems that may be mediating the effects of these modulators. Bath application of… CONTINUE READING
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