Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain.

@article{Cousin1995ModulationOI,
  title={Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain.},
  author={Michael A. Cousin and David G. Nicholls and Jennifer M. Pocock},
  journal={Journal of neurochemistry},
  year={1995},
  volume={64 5},
  pages={2097-104}
}
Upon addition of the cardiac glycoside ouabain to cultured cerebellar granule cells, an immediate increase in intracellular free sodium is evoked mediated by two pathways, a voltage-sensitive channel blocked by tetrodotoxin and a channel sensitive to flunarizine. Ouabain induces a steady plasma membrane depolarization in low Ca2+ medium; whereas in the presence of Ca2+, a distinct discontinuity is observed always preceded by a large increase in intracellular free Ca2+ ([Ca2+]c). The plateau… CONTINUE READING

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