Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging?

@article{Annunziato2002ModulationOI,
  title={Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging?},
  author={Lucio Annunziato and Anna Pannaccione and Mauro Cataldi and Agnese Secondo and Pasqualina Castaldo and Gianfranco F Di Renzo and Maurizio Taglialatela},
  journal={Neurobiology of aging},
  year={2002},
  volume={23 5},
  pages={819-34}
}
An ever increasing number of reports shows the involvement of free radicals in the functional and structural changes occurring in the brain as a part of the "normal" aging process. Given that plasma membrane and intracellular ion channels play a critical role in maintaining intracellular ion homeostasis, which is crucial for neuronal cell survival, in the present review we have attempted to elaborate on the idea that functional changes in ion channel activity induced by reactive oxygen species… CONTINUE READING

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