Modulation of intracellular reactive oxygen species level in chondrocytes by IGF-1, FGF, and TGF-beta1.

@article{Jallali2007ModulationOI,
  title={Modulation of intracellular reactive oxygen species level in chondrocytes by IGF-1, FGF, and TGF-beta1.},
  author={Navid Jallali and Hyder Ridha and Christopher Thrasivoulou and Peter Butler and Timothy Cowen},
  journal={Connective tissue research},
  year={2007},
  volume={48 3},
  pages={149-58}
}
Growth factors are important in the development, maintenance and repair of cartilage. The principal aim of this study was to test the capacity of three growth factors with established roles in cartilage, namely insulin-like growth factor (IGF)-1, fibroblast growth factor (FGF) and transforming growth factor (TGF)-beta 1, to alter intracellular reactive oxygen species (ROS) levels. Explants of articular cartilage from young, mature, and aged rats were pretreated with IGF-1, FGF, or TGF-beta 1… CONTINUE READING

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