Modulation of intracellular pH in human ovarian cancer.

  title={Modulation of intracellular pH in human ovarian cancer.},
  author={Carlos Sanhueza and Joaqu{\'i}n Araos and Luciano Naranjo and Roberto Villalobos and Francisco Westermeier and Carlos Salomon and Ana Rosa Beltr{\'a}n and Marco A. Ram{\'i}rez and Jorge Guti{\'e}rrez and Fernando Pardo and Andrea Leiva and Luis Sobrevia},
  journal={Current molecular medicine},
  volume={16 1},
To sustain tumor growth, the cancer cells need to adapt to low levels of oxygen (i.e., hypoxia) in the tumor tissue and to the tumor-associated acidic microenvironment. In this phenomenon, the activation of the sodium/proton exchanger 1 (NHE1) at the plasma membrane and the hypoxia-inducible factor (HIF) are critical for the control of the intracellular pH (pHi) and for hypoxia adaptation, respectively. Interestingly, both of these mechanisms end in sustaining cancer cell proliferation. However… CONTINUE READING
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