Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells.

@article{Dai2002ModulationOI,
  title={Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells.},
  author={Junsheng Dai and Edward W. Inscho and Lin Yuan and Steven Marc Hill},
  journal={Journal of pineal research},
  year={2002},
  volume={32 2},
  pages={
          112-9
        }
}
The pineal hormone, melatonin, has been shown to inhibit the proliferation of the estrogen receptor alpha (ERalpha)-positive macrophage chemotactic factor (MCF)-7 human breast cancer cells. Previous studies from other systems indicate that melatonin modulates the calcium (Ca2+)/calmodulin (CaM) signaling pathway either by changing intracellular calcium concentration ([Ca2+]i) via activation of its G-protein coupled membrane receptors, or through a direct interaction with CaM. In this study… CONTINUE READING
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