Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells.

Abstract

Cerebral ischaemia rapidly depletes cellular ATP. Whilst this deprives brain tissue of a valuable energy source, the concomitant production of adenosine mitigates the damaging effects of energy failure by suppressing neuronal activity. However, the production of adenosine and other metabolites, and their loss across the blood-brain barrier, deprives the… (More)
DOI: 10.1111/jnc.12397

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Cite this paper

@article{Nedden2014ModulationOI, title={Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells.}, author={Stephanie zur Nedden and Alexander Doney and Bruno G Frenguelli}, journal={Journal of neurochemistry}, year={2014}, volume={128 1}, pages={111-24} }