Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors.

@article{Flood2007ModulationOI,
  title={Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors.},
  author={Sophie Flood and Rheinallt Parri and Anwen A. Williams and Victor C. Duance and Deborah Mason},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 8},
  pages={2523-34}
}
OBJECTIVE Patients with rheumatoid arthritis (RA) have increased concentrations of the amino acid glutamate in synovial fluid. This study was undertaken to determine whether glutamate receptors are expressed in the synovial joint, and to determine whether activation of glutamate receptors on human synoviocytes contributes to RA disease pathology. METHODS Glutamate receptor expression was examined in tissue samples from rat knee joints and in human fibroblast-like synoviocytes (FLS). FLS from… CONTINUE READING
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