Modulation of interleukin-1 receptor expression and interleukin-1 response in fibroblasts by platelet-derived growth factor.

@article{Bonin1988ModulationOI,
  title={Modulation of interleukin-1 receptor expression and interleukin-1 response in fibroblasts by platelet-derived growth factor.},
  author={Paul D Bonin and Jai Pal Singh},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 23},
  pages={11052-5}
}
Our studies have revealed that the interleukin-1 (IL-1) receptors and response in BALB/c/3T3 fibroblasts are modulated by platelet-derived growth factor (PDGF). Incubation of quiescent cultures of BALB/c/3T3 fibroblasts with PDGF resulted in 4-5 fold higher 125I-IL-1 binding than the untreated cultures. Scatchard analysis showed that the increased 125I-IL-1 binding by PDGF-treated cells was due to a net increase in cell surface IL-1 receptors with no apparent change in binding affinity. The… CONTINUE READING

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