Modulation of insulin degrading enzyme activity and liver cell proliferation.

  title={Modulation of insulin degrading enzyme activity and liver cell proliferation.},
  author={O. A. Pivovarova and Christian von Loeffelholz and Iryna Ilkavets and Carsten Sticht and Sergei Zhuk and Veronica Murahovschi and Sonja Lukowski and Stephanie Doecke and Jennifer Kriebel and Tonia de las Heras Gala and Anna Malashicheva and Anna Kostareva and J F Lock and Martin Stockmann and Harald Grallert and Norbert Gretz and Steven Dooley and Andreas F. H. Pfeiffer and Natalia Rudovich},
  journal={Cell cycle},
  volume={14 14},
Diabetes mellitus type 2 (T2DM), insulin therapy, and hyperinsulinemia are independent risk factors of liver cancer. Recently, the use of a novel inhibitor of insulin degrading enzyme (IDE) was proposed as a new therapeutic strategy in T2DM. However, IDE inhibition might stimulate liver cell proliferation via increased intracellular insulin concentration. The aim of this study was to characterize effects of inhibition of IDE activity in HepG2 hepatoma cells and to analyze liver specific… CONTINUE READING
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