Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors.

@article{Bliska2013ModulationOI,
  title={Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors.},
  author={James B Bliska and Xiaoying Wang and Gloria I. Viboud and Igor E Brodsky},
  journal={Cellular microbiology},
  year={2013},
  volume={15 10},
  pages={1622-31}
}
The innate immune system of mammals responds to microbial infection through detection of conserved molecular determinants called 'pathogen-associated molecular patterns' (PAMPs). Pathogens use virulence factors to counteract PAMP-directed responses. The innate immune system can in turn recognize signals generated by virulence factors, allowing for a heightened response to dangerous pathogens. Many Gram-negative bacterial pathogens encode type III secretion systems (T3SSs) that translocate… CONTINUE READING
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