Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase

Abstract

Poly(ADPR) polymerase (PARP; EC 2.4.2.30) is a nuclear enzyme, which, when activated by oxygen- and nitrogen-radical-induced DNA strand breaks, transfers ADP ribose units to nuclear proteins and initiates apoptosis by depletion of cellular NAD and ATP pools. The present study investigates whether the oxidative stressdependent activation of PARP plays a role… (More)
DOI: 10.1007/BF01534394

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