Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering.

@article{Wenger2004ModulationOI,
  title={Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering.},
  author={Andreas Wenger and Andreas Stahl and Helen Weber and Gunter Finkenzeller and Hellmut G Augustin and Gerhard Bjoern Stark and Ulrich Kneser},
  journal={Tissue engineering},
  year={2004},
  volume={10 9-10},
  pages={1536-47}
}
One of the major challenges in tissue engineering of bone substitutes remains vascularization of the transplant. We have developed a three-dimensional collagen-based coculture system to assess interactions between human endothelial cells (hECs) and human osteoblasts (hOBs) in vitro. Human umbilical vein endothelial cells (HUVECs) were grown as three-dimensional multicellular spheroids and seeded in a collagen matrix to assess sprouting of the spheroids, that is, formation of tubelike structures… CONTINUE READING

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