Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults.

@article{Smith2016ModulationOI,
  title={Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults.},
  author={Christopher T. Smith and Deanna L Wallace and Linh C. Dang and Esther Aarts and William J. Jagust and Mark D'Esposito and Charlotte A. Boettiger},
  journal={Journal of neurophysiology},
  year={2016},
  volume={115 3},
  pages={1146-56}
}
Converging evidence links individual differences in mesolimbic and mesocortical dopamine (DA) to variation in the tendency to choose immediate rewards ("Now") over larger, delayed rewards ("Later"), or "Now bias." However, to date, no study of healthy young adults has evaluated the relationship between Now bias and DA with positron emission tomography (PET). Sixteen healthy adults (ages 24-34 yr; 50% women) completed a delay-discounting task that quantified aspects of intertemporal reward… CONTINUE READING
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