Modulation of immune system function by measles virus infection: role of soluble factor and direct infection.

@article{Fujinami1998ModulationOI,
  title={Modulation of immune system function by measles virus infection: role of soluble factor and direct infection.},
  author={Robert Shin Fujinami and Xuejun Sun and Joseph M Howell and James C Jenkin and J. Bradley Burns},
  journal={Journal of virology},
  year={1998},
  volume={72 12},
  pages={9421-7}
}
Measles virus infection can result in a variety of immunologic defects. We have begun studies to determine the basis for the lack of immune responsiveness to antigen and mitogen following infection. Here we present data showing that Epstein-Barr virus-transformed B-cell lines infected with measles virus produce a soluble factor that can inhibit antigen-specific T-cell proliferation and inhibit the proliferation of uninfected B cells. The soluble factor was neither interleukin-10, transforming… CONTINUE READING
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