Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades.

@article{Feldman2005ModulationOH,
  title={Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades.},
  author={Jack L Feldman and Natalia V Neverova and Shane A Saywell},
  journal={Respiratory physiology & neurobiology},
  year={2005},
  volume={147 2-3},
  pages={131-43}
}
Motoneuronal excitability is highly modulated by various inputs; however, comparatively little is known about postsynaptic signal transduction cascades that affect motoneuron excitability. In this review, we discuss the role of intracellular signaling cascades in the modulation of respiratory motoneuronal excitability. In particular, protein kinases and phosphatases dynamically and constitutively modulate respiratory-modulated inputs to XII motoneurons: (i) activation of protein kinase A (PKA… CONTINUE READING

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