Modulation of human saposin B sphingolipid-binding specificity by alternative splicing. A study with saposin B-derived synthetic peptides.


The saposins A, B, C, and D, produced by proteolytic maturation of the same precursor protein, prosaposin, are sphingolipid-binding proteins which function as activators for lysosomal enzymes involved in sphingolipid hydrolysis. The alternative splicing of the prosaposin gene results in the inclusion or exclusion of exon 8 into transcribed prosaposin mRNA… (More)


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