Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29).


The type III family of IFNs displays immunomodulatory and antiviral activity. Each member (IFN-lambda1, -2, and -3) signals through the same heterodimeric receptor complex, which consists of the binding and signaling subunit (IL-28Ralpha) plus the IL-10Rbeta chain. Although the receptor has a wide tissue distribution, the direct effects of IFN-lambda on… (More)
DOI: 10.1189/jlb.0509347


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