Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.

@article{Salio2007ModulationOH,
  title={Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.},
  author={Mariolina Salio and Anneliese O Speak and Dawn Shepherd and Paolo Polzella and Petr Illarionov and Natacha Veerapen and Gurdyal S Besra and Frances M Platt and Vincenzo Cerundolo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 51},
  pages={20490-5}
}
Invariant natural killer T (iNKT) cells are a subset of nonconventional T cells recognizing endogenous and/or exogenous glycolipid antigens in the context of CD1d molecules. It remains unclear whether innate stimuli can modify the profile of endogenous lipids recognized by iNKT cells on the surface of antigen-presenting cells (APCs). We report that activation of human APCs by Toll-like receptor ligands (TLR-L) modulates the lipid biosynthetic pathway, resulting in enhanced recognition of CD1d… CONTINUE READING

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