Modulation of human leukocyte antigen class I expression by gamma interferon in head and neck cancer cell lines.

@article{Houck1988ModulationOH,
  title={Modulation of human leukocyte antigen class I expression by gamma interferon in head and neck cancer cell lines.},
  author={James R. Houck and Tariq Shah and Betsy M. Ohlsson-Wilhelm and E D Kloszewski and Betty R. Conner},
  journal={American journal of otolaryngology},
  year={1988},
  volume={9 5},
  pages={
          217-23
        }
}
One possible mechanism explaining the action of interferon (IFN) on squamous cell carcinoma (SqCC) of the head and neck is the modulation of major histocompatibility antigen expression on tumor cells. We tested the ability of gamma interferon (gamma-IFN) to modulate major histocompatibility class I antigens and beta 2-microglobulin (beta 2-M) on two carcinoma cell lines derived from SqCC of the head and neck. Major histocompatibility class I antigens and beta 2-M were detected using a two-step… CONTINUE READING