Modulation of human bronchial epithelial cells by pneumococcal choline binding protein A.

@article{Cao2011ModulationOH,
  title={Modulation of human bronchial epithelial cells by pneumococcal choline binding protein A.},
  author={Ju Cao and Yi Gong and Bei Cai and Weihua Feng and Yongkang Wu and Lixin Li and Yuangao Zou and B. A. Ying and Lanlan Wang},
  journal={Human immunology},
  year={2011},
  volume={72 1},
  pages={37-46}
}
Choline binding protein A (CbpA) is an important adhesin and a determinant of virulence for Streptococcus pneumoniae. Binding to epithelial cells of host mucosal surfaces by pneumococcal CbpA is essential for pneumococcus to initiate colonization and to trigger subsequent invasive pneumococcal infections. In this study, we examined the immunopathologic mechanisms for the activation of human bronchial epithelial cells by CbpA in pneumococcal infections. Adhesion molecules, cytokines, and… CONTINUE READING