Modulation of human and mouse erythropoiesis by thyroid hormone and retinoic acid: evidence for specific effects at different steps of the erythroid pathway.

@article{Perrin1997ModulationOH,
  title={Modulation of human and mouse erythropoiesis by thyroid hormone and retinoic acid: evidence for specific effects at different steps of the erythroid pathway.},
  author={Marc-Antoine Perrin and J. P. Blanchet and Guy Mouchiroud},
  journal={Hematology and cell therapy},
  year={1997},
  volume={39 1},
  pages={19-26}
}
Receptors for L-triiodothyronine (T3) and alltrans retinoic acid (ATRA) are DNA-binding proteins that can form transcriptionally active heterodimers. In this study, we sought whether T3 and ATRA could cooperate to modulate human and mouse erythropoiesis in vitro. Effects of T3 and ATRA were first assessed on burst forming unit-erythroid (BFU-E) proliferation and differentiation in semi-solid cultures. T3 did not alter the cloning efficiency of BFU-E but it decreased the production of colony… CONTINUE READING