Modulation of human Vα24+Vβ11+ NKT cells by age, malignancy and conventional anticancer therapies

@article{Crough2004ModulationOH,
  title={Modulation of human Vα24+Vβ11+ NKT cells by age, malignancy and conventional anticancer therapies},
  author={Tania Crough and David M. Purdie and Miki Okai and Abdel Maksoud and M Nieda and Andrew J. Nicol},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={1880 - 1886}
}
Immunotherapy strategies aimed at increasing human Vα24+Vβ11+ natural killer T (NKT) cell numbers are currently a major focus. To provide further information towards the goal of NKT cell-based immunotherapy, we assessed the effects of age, cancer status and prior anticancer treatment on NKT cell numbers and their expansion capacity following α-galactosylceramide (α-GalCer) stimulation. The percentage and absolute number of peripheral blood NKT cells was assessed in 40 healthy donors and 109… CONTINUE READING
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