Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4.

@article{Holt2012ModulationOH,
  title={Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4.},
  author={Dawn M Holt and Xinrong Ma and Namita Kundu and Peter D. Collin and Amy M. Fulton},
  journal={Journal of immunotherapy},
  year={2012},
  volume={35 2},
  pages={
          179-88
        }
}
Breast malignancies often have high levels of COX-2. The COX-2 product prostaglandin E2 (PGE2) contributes to the high metastatic capacity of breast tumors. Our published data indicate that inhibiting either PGE2 production or PGE2-mediated signaling through the PGE2 receptor EP4 (1 of 4 EP expressed on the malignant cell) reduces metastasis by a mechanism that requires natural killer (NK) cells. Tumor-derived PGE2 and exogenous PGE2 are known to have direct inhibitory effects on NK cell… CONTINUE READING
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Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?

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The roles of the COX2/PGE2/EP axis in therapeutic resistance

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