Modulation of hexachlorobenzene-induced hepatic porphyria by methyl isobutyl ketone in the rat.

@article{Krishnan1992ModulationOH,
  title={Modulation of hexachlorobenzene-induced hepatic porphyria by methyl isobutyl ketone in the rat.},
  author={Kannan Krishnan and Jacques Brodeur and Gabriel L. Plaa and Michel Charbonneau},
  journal={Toxicology letters},
  year={1992},
  volume={61 2-3},
  pages={167-74}
}
Potential toxic interaction between hexachlorobenzene (HCB) and methyl isobutyl ketone (MiBK) was investigated using two different schedules of toxicant administration. The first schedule involved simultaneous administration of HCB (50 mg/kg/d, p.o. in 10 ml/kg corn oil at 10.00 a.m. for 5 d/wk) and MiBK (7.5 mmol/kg/d, p.o. in 10 ml/kg corn oil at 4.00 p.m… CONTINUE READING