Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis.

@article{Labont2002ModulationOH,
  title={Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis.},
  author={Patrick Labont{\'e} and Vladimir Axelrod and Atul P. Agarwal and Ann Aulabaugh and Anthony Amin and Paul O T Mak},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 41},
  pages={38838-46}
}
The hepatitis C virus (HCV) encodes an RNA-dependent RNA polymerase (NS5B), which is indispensable for the viral genome replication. Although structural comparison among HCV NS5B, poliovirus 3D-pol, and human immunodeficiency virus-reverse transcriptase RNA-dependent polymerase reveals the canonical palm, fingers, and thumb domains, the crystal structure of HCV NS5B highlights the presence of a unique A1-loop, which extends from the fingers to the thumb domain (amino acids 12-46), providing… CONTINUE READING

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