Modulation of hepatic gene expression by alpha-tocopherol in cultured cells and in vivo.

Abstract

To obtain a comprehensive understanding of the molecular mechanisms of action of vitamin E (VE), global gene expression profiles using DNA arrays in rat liver and hepatocellular liver carcinoma cells (HepG2) were obtained. For the analysis of short-term (49 days) and long-term (290 days) VE deficiency, rats were fed semisynthetic diets either supplemented… (More)

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