Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases.

@article{Guo2001ModulationOH,
  title={Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases.},
  author={Xia Guo and Vivian Yvonne Shin and Cho H Cho},
  journal={Life sciences},
  year={2001},
  volume={69 25-26},
  pages={
          3113-9
        }
}
Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of biliverdin, free iron and carbon monoxide (CO). There are three isoforms of HO: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed. In addition to heme, a variety of nonheme compounds, including heavy metals, cytokines, endotoxins and heat shock stress are strong inducers of HO-1 expression. Many studies indicated that induction of HO-1 is associated with a protective… CONTINUE READING