Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain.

@article{Ohbo1996ModulationOH,
  title={Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain.},
  author={Kazuyuki Ohbo and Toshio Suda and M Hashiyama and Akio Mantani and Mika Ikebe and Kazuhisa Miyakawa and Masatsugu Moriyama and Masahiko Nakamura and Motoya Katsuki and Kiyoshi Takahashi and Ken-ichi Yamamura and Kazuo Sugamura},
  journal={Blood},
  year={1996},
  volume={87 3},
  pages={956-67}
}
The interleukin-2 (IL-2) receptor gamma chain is indispensable for IL-2-, IL-4-, IL-7-, IL-9-, and IL-15-mediated signaling. Mutations of the human gamma chain cause the X-linked severe combined immunodeficiency (XSCID), showing that T and natural killer cells absolutely require the gamma chain for their development in humans. To elucidate the roles of the gamma chain in hematopoiesis, we have generated mice, by gene targeting, that express a form of the gamma chain lacking the cytoplasmic… CONTINUE READING

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