Modulation of growth of vascular smooth muscle cells by activin A.

  title={Modulation of growth of vascular smooth muscle cells by activin A.},
  author={Itaru Kojima and Heitaro Mogami and Norio Kawamura and Hiroshi Yasuda and Hiroshi Shibata},
  journal={Experimental cell research},
  volume={206 1},
Activin A is a homodimeric protein structurally related to transforming growth factor-beta. The present study was conducted to examine the effect of activin A on the growth of rat vascular smooth muscle cells (VSMC) in culture. When serum-deprived cells were incubated with activin A, nuclear labeling of bromodeoxyuridine occurred after a 12-h lag period. The effect of activin A on nuclear labeling was dose-dependent, being maximal at 10(-9) M. Activin A also increased the number of VSMC after… CONTINUE READING
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