Modulation of growth hormone action by sex steroids

@article{Meinhardt2006ModulationOG,
  title={Modulation of growth hormone action by sex steroids},
  author={Udo J. Meinhardt and Ken K Y Ho},
  journal={Clinical Endocrinology},
  year={2006},
  volume={65}
}
Growth hormone (GH) is a major regulator of growth, somatic development and body composition. Sex steroids can act centrally by regulating GH secretion and peripherally modulating GH responsiveness. This review addresses data of potential clinical relevance on how sex steroids modulate GH secretion and action, aiming to increase the understanding of sex steroid/GH interactions and leading to improved management of patients. Sex steroids regulate GH secretion directly as well as indirectly… Expand

Paper Mentions

Interventional Clinical Trial
12 adult hypopituitary patients with newly diagnosed Growth hormone (GH)-deficiency will be studied two times. The first examinations will be performed shortly after time of diagnose… Expand
ConditionsGrowth Hormone Deficiency, Growth Hormone Treatment
InterventionDrug
Sex steroids and growth hormone interactions.
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A better understanding of these interactions in physiological and pathological states will contribute to preserve health and to improve clinical management of patients with growth, developmental, and metabolic disorders. Expand
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TLDR
A better understanding of these interactions in physiological and pathological states will contribute to preserve health and to improve clinical management of patients with growth, developmental, and metabolic disorders. Expand
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TLDR
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TLDR
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Estrogens in the Control of Growth Hormone Actions in Liver
TLDR
Global expression analysis of GH actions in liver using microarrays clearly indicates that most of the known physiological effects of GH can be explained through its effects on the transcription of specific genes. Expand
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TLDR
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TLDR
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Testosterone, 17β-estradiol and pubertal growth
Background and aims: It is well established that the interaction of sex steroids with the growth hormone (GH)/ insulin-like growth factor 1 (IGF-1) axis is of major importance in children for normalExpand
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References

SHOWING 1-10 OF 96 REFERENCES
Estrogen regulation of growth hormone action.
TLDR
There is strong evidence that oral but not transdermal administration of estrogen impairs the metabolic action of GH in the liver, causing a fall in IGF-I production and fat oxidation and an impairment of GH effect in hypopituitary women on GH replacement. Expand
The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence.
TLDR
It has been possible to demonstrate that the mechanism of this increase is via sex steroid hormone-induced amplification of endogenous GH production rate, without demonstrable alterations of the frequency of secretory episodes or of hormone half-life. Expand
Divergent effect of endogenous and exogenous sex steroids on the insulin-like growth factor I response to growth hormone in short normal adolescents.
TLDR
Endogenous gonadal steroid secretion appears to result in increased responsiveness to GH in peripubertal girls and boys, suggesting a link between the energy stores and the anabolic action of GH. Expand
Gender and hormonal regulation of growth.
  • A. Rogol
  • Medicine
  • Journal of pediatric endocrinology & metabolism : JPEM
  • 2004
TLDR
The interplay between the somatotropic and gonadotropic hormone axes during puberty has profound implications on the treatment of adolescent patients in need of hormone replacement therapy for growth deficiency or hypogonadism. Expand
Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boys.
TLDR
GH and T are synergistic on whole body protein anabolism and body composition in males, even at a young age, but the positive effects of T on protein anabolicism andBody composition appear to need a basal amount of GH for those effects to be observed. Expand
Activation of the Somatotropic Axis by Testosterone in Adult Men: Evidence for a Role of Hypothalamic Growth Hormone-Releasing Hormone
Testosterone (T) is known to affect the growth hormone (GH) axis. However, the mechanisms underlying the activation of GH secretion by T still remain to be clarified. Available data in animals andExpand
Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy.
TLDR
Supraphysiological testosterone concentrations augment GH and IGF-I production in the elderly male without altering maximal somatotrope responses to single and combined GHRH and GHRP-2 drive, thus predicting multifactorial mechanisms of testosterone upregulation. Expand
Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women.
TLDR
Oral estrogen antagonizes several of the metabolic actions of GH and may aggravate body composition abnormalities already present in GHD women and attenuate the beneficial effects of GH therapy, which should be administered by a nonoral route. Expand
Testosterone-induced increase of insulin-like growth factor I levels depends upon normal levels of growth hormone.
TLDR
The study during the hCG test in boys with various clinical conditions demonstrated an increase in IGF-I concentrations only in those boys with sufficient GH secretion or GH replacement therapy, indicating that both sex steroids and GH are necessary to allow for the pubertal increase inFG-I levels. Expand
Anabolic and androgenic affect of testosterone in sexually immature boys and its dependency on growth hormone.
TLDR
The effect of a long-acting testosterone preparation on growth, on skeletal maturation and on secondary sex characteristics was studied in 24 boys with sexual immaturity of different causes, finding that in patients with growth hormone deficiency the response is less marked. Expand
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