Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.

  title={Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.},
  author={Zheng-Xiong Xi and Sammanda Ramamoorthy and David A. Baker and Hui Shen and Devadoss John Samuvel and Peter W. Kalivas},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={303 2},
Repeated cocaine produces enduring neuroadaptations in glutamate transmission in the nucleus accumbens that are thought to contribute to addiction. Group II metabotropic glutamate autoreceptors (mGluR2/3) regulate glutamate release, and this study investigates whether repeated cocaine injection produces long-lasting alterations in mGluR2/3 content, phosphorylation, and physiology. Rats were administered cocaine daily for 1 week, and 3 weeks after the last injection, mGluR2/3 protein levels were… CONTINUE READING


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