Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.

@article{Xi2002ModulationOG,
  title={Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.},
  author={Zheng-Xiong Xi and Sammanda Ramamoorthy and David A. Baker and Hui Shen and Devadoss John Samuvel and Peter W. Kalivas},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={303 2},
  pages={608-15}
}
Repeated cocaine produces enduring neuroadaptations in glutamate transmission in the nucleus accumbens that are thought to contribute to addiction. Group II metabotropic glutamate autoreceptors (mGluR2/3) regulate glutamate release, and this study investigates whether repeated cocaine injection produces long-lasting alterations in mGluR2/3 content, phosphorylation, and physiology. Rats were administered cocaine daily for 1 week, and 3 weeks after the last injection, mGluR2/3 protein levels were… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

The primary source and neuronal function of extracellular glutamate

  • DA Baker, Z-X Xi, H Shen, CJ Swanson, PW Kalivas
  • J Neurosci,
  • 2002
Highly Influential
7 Excerpts

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

  • ME Wolf
  • Prog Neurobiol
  • 1998
Highly Influential
7 Excerpts

Cocaine and G-protein plasticity

  • MS Bowers, ML Bernard, SM Lanier, PW Kalivas
  • 31st Annual Neuroscience Meeting;
  • 2001
2 Excerpts

Similar Papers

Loading similar papers…