Modulation of glutathione S-transferase alpha by hepatitis B virus and the chemopreventive drug oltipraz.

@article{JaitovitchGroisman2000ModulationOG,
  title={Modulation of glutathione S-transferase alpha by hepatitis B virus and the chemopreventive drug oltipraz.},
  author={I Jaitovitch-Groisman and Nasser Fotouhi-Ardakani and Robyn L. Schecter and Annie Woo and Moulay A. Alaoui-Jamali and Gerald Batist},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 43},
  pages={33395-403}
}
Persistent infection by hepatitis B virus (HBV) and exposure to chemical carcinogens correlates with the prevalence of hepatocellular carcinoma in endemic areas. The precise nature of the interaction between these factors is not known. Glutathione S-transferases (GST) are responsible for the cellular metabolism and detoxification of a variety of cytotoxic and carcinogenic compounds by catalysis of their conjugation with glutathione. Diminished GST activity could enhance cellular sensitivity to… CONTINUE READING