Modulation of glutamate release from rat hippocampal synaptosomes by nitric oxide.

@article{Sequeira1997ModulationOG,
  title={Modulation of glutamate release from rat hippocampal synaptosomes by nitric oxide.},
  author={Sunitha M Sequeira and Ant{\'o}nio Francisco Ambr{\'o}sio and Jo{\~a}o Oliveira Malva and Ars{\'e}lio Pato Carvalho and Caetana Monteiro Carvalho},
  journal={Nitric oxide : biology and chemistry},
  year={1997},
  volume={1 4},
  pages={315-29}
}
We used hippocampal synaptosomes to study the effect of NO originating from NO donors and from the activation of the NO synthase on the Ca2+-dependent release of glutamate due to 4-aminopyridine (4-AP) depolarization. We distinguished between the effects of NO on the exocytotic and on the carrier-mediated release of glutamate, which we found to be related to an increase in cGMP content and to a reduction of the ATP/ADP ratio, respectively. The NO donor hydroxylamine, at concentrations < or = 0… CONTINUE READING

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