Modulation of glutamate receptor functions by glutathione

@article{Oja2000ModulationOG,
  title={Modulation of glutamate receptor functions by glutathione},
  author={S. S. Oja and R{\'e}ka Jan{\'a}ky and Vince Varga and Pirjo Saransaari},
  journal={Neurochemistry International},
  year={2000},
  volume={37},
  pages={299-306}
}
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112 Citations

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This model explains how higher levels of GSH can reverse the downstream pathophysiological effects of a hyperglutamatergic state in FES, and provides an initial insight into the possible mechanistic effect of antioxidant system on the excitatory overdrive in the salience network (dACC-AI).

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Thinking Outside the Cleft to Understand Synaptic Activity: Contribution of the Cystine-Glutamate Antiporter (System xc−) to Normal and Pathological Glutamatergic Signaling

The major cellular components that regulate glutamate homeostasis, including glutamate release by system xc− are discussed, followed by an in-depth discussion of system x c− as it relates to glutamate release, cystine transport, and glutathione synthesis.

Involvement of Amino-Acid Side Chains of Membrane Proteins in the Binding of Glutathione to Pig Cerebral Cortical Membranes

The results indicate that cysteinyl side chains and disulfide bonds are essential in the binding of GSH to membrane proteins and that arginyl and lysylSide chains may also be directly involved in this process.

Ammonia toxicity to the brain and creatine.

Behavioral and biochemical effects of glutathione depletion in the rat brain

The role of glutathione redox imbalance in autism spectrum disorder: A review.

Glutathione Pathways in the Brain

Results on the export of GSH and GSSG from brain cells as well as on the functions of extracellular GSH in the brain are reviewed and implications of disturbed GSH pathways in brain for neurodegenerative diseases will be discussed.

Zinc toxicity on neonatal cortical neurons: involvement of glutathione chelation

The results suggest that zinc non‐enzymatically depleted GSH, an intrinsic factor for neuron survival, leading to activation of the cellular death signal and eventually neuronal death.
...

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