Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL-1 beta, TNF-alpha and LPS.

@article{Verheggen1996ModulationOG,
  title={Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL-1 beta, TNF-alpha and LPS.},
  author={Michiel Verheggen and Peter Th W van Hal and P. W. C. Adriaansen-Soeting and B. J. A. Goense and Henk C. Hoogsteden and Albert O. Brinkmann and Marjan A. Versnel},
  journal={The European respiratory journal},
  year={1996},
  volume={9 10},
  pages={2036-43}
}
Bronchial epithelium plays a major role in the regulation of inflammatory reactions in the airways. It is thought to be a possible target for glucocorticoid therapy. Glucocorticoid responsiveness requires the presence of specific glucocorticoid receptors (GR). Until now, little was known about the presence of such receptors in the human bronchial epithelium. In this study we demonstrated the expression of GR messenger ribonucleic acid (mRNA) in two simian virus (SV)-40/adenovirus-transformed… CONTINUE READING
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